This paper presents simulations of a three-dimensional model of the bone remodelling process. The model consists of a set of variable order partial differential equations, in which the varying order depends on the presence of tumour cells. The simulations are of a two-dimensional bone, to make visualisation simpler. They show that this model corresponds to the known evolution of bone remodelling, and is simpler than integer order models found in the literature.

In this paper a sample rate conversion algorithm which allows for continuously changing resampling ratio has been presented. The proposed implementation is based on a variable fractional delay filter which is implemented by means of a Farrow structure. Coefficients of this structure are computed on the basis of fractional delay filters which are designed using the offset window method. The proposed approach allows us to freely change the instantaneous resampling ratio during processing. Using such an algorithm we can simulate recording of audio on magnetic tape with nonuniform velocity as well as remove such distortions. We have demonstrated capabilities of the proposed approach based on the example of speech signal processing with a resampling ratio which was computed on the basis of estimated fundamental frequency of voiced speech segments.

A steam generator in a nuclear power plant with a light water reactor is a heat exchanger, in which the heat is being transferred from the primary to the secondary loop (it links the primary and secondary loops). When the power plant is running, the inlet parameters (temperatures and mass flow rates) on both sides of the steam generator can change. It is important to know how the changes of these parameters affect the steam generator performance. The complexity of the processes taking place in the steam generator makes it difficult to create a simulator reflecting its performance under changed conditions. In order to simplify the task, the steam generator was considered as a ‘black box’ with the aim of examining how the changes of the inlet parameters affect the changes of the outlet ones. On the basis of the system (steam generator) response, a simple mathematical model of the steam generator under variable load conditions was proposed. In the proposed model, there are two dimensionless parameters and three constant coefficients. A linear relation between these dimensionless parameters was obtained. The correctness of the model was verified against the data obtained with a steam generator simulator for European Pressured Reactor and AP-600 reactors. A good agreement between the proposed model and the simulator data was achieved.

Compared with the robots, humans can learn to perform various contact tasks in unstructured environments by modulating arm impedance characteristics. In this article, we consider endowing this compliant ability to the industrial robots to effectively learn to perform repetitive force-sensitive tasks. Current learning impedance control methods usually suffer from inefficiency. This paper establishes an efficient variable impedance control method. To improve the learning efficiency, we employ the probabilistic Gaussian process model as the transition dynamics of the system for internal simulation, permitting long-term inference and planning in a Bayesian manner. Then, the optimal impedance regulation strategy is searched using a model-based reinforcement learning algorithm. The effectiveness and efficiency of the proposed method are verified through force control tasks using a 6-DoFs Reinovo industrial manipulator.

A strip yield model implementation by the present authors is applied to predict fatigue crack growth observed in structural steel specimens under various constant and variable amplitude loading conditions. Attention is paid to the model calibration using the constraint factors in view of the dependence of both the crack closure mechanism and the material stress-strain response on the load history. Prediction capabilities of the model are considered in the context of the incompatibility between the crack growth resistance for constant and variable amplitude loading.

A novel type of an axial, piston-driven high pressure hydraulic pump with variable capacity marks a significant improvement in the area of the hydraulic machinery design. Total discharge from hydrostatic forces eliminates a need for a servomechanism, thus simplifying operation, reducing weight and introducing the possibility of the pump displacement control by computer. PWK-type pumps, invented in the Gdansk University of Technology, offer high efficiency for pressure levels up to 55 MPa, ability to work self sucking even at high speed. However, the heart of the new invention, the commutation unit, creates harmful pressure peaks. Those peaks can be mitigated by the introduction of a compensation chamber with elastic walls. Owing to the dynamic character of events taking place in the pump, a need for computer simulation arouse in order to understand phenomena leading to the occurrence of pressure peaks and choose compensation chamber parameters accordingly. A CFD package alone would not be sufficient to reliably represent the interaction between the compensation chamber wall and the working fluid. This paper presents Fluid Structure Interaction approach comparing 3 different models: 2 simplified models of the pump and a full pump model.

In the present article, we introduced a new model of the equations of general ized thermoelasticity for unbounded orthotropic body containing a cylindrical cavity. We applied this model in the context of generalized thermoelasticity with phase-lags under the effect of rotation. In this case, the thermal conductivity of the material is considered to be variable. In addition, the cylinder surface is traction free and subjected to a uniform unit step temperature. Using the Laplace transform technique, the distributions of the temperature, displacement, radial stress and hoop stress are determined. A detailed analysis of the effects of rotation, phase-lags and the variability thermal conductivity parameters on the studied fields is discussed. Numerical results for the studied fields are illustrated graphically in the presence and absence of rotation.

The Variable Frequency Drive (VFD) is used to control the speed of the pumpmotor to attain the desired flow rate and fluid level in a fluid system. An AC drive provides efficient flow control by varying the pump-motor speed. The comparison of energy requirements and costs in a system where a throttling device is used for flow control on a centrifugal pump with the power used when an variable frequency drive (VFD) is used to control the same flow, evidently shows potential savings. In this system, AC Motor Frequency drive and static pressure transmitter, turbine type flowmeter and Analog/Digital cards, micro-control unit and computer connection are designed specially to control flow rate, fluid flow type (turbulence or laminar) and water level at the different conditions with different PID parameters.

The occurrence of gas confined in shales allows us to consider it as a component of the host rock. During drilling wells, the gas is released into the drilling fluid from finely ground gas-bearing rock particles. The amount of gas released can be determined on the basis of mud-gas logging; in addition, it is possible to determine the gas-content in shales expressed by the volume of gas released per mass unit of rock [m3/ton]. The gas content in the Ordovician and Silurian shales (Sasin formation and Jantar member respectively) in two selected wells in northern Poland was determined using this method. It has been found that clearly distinguishable, highly gas-bearing sections, which are separated by very poorly gas-bearing ones, can be determined in the well log. The increased gas content in shales can be observed in zones generally enriched in TOC. No direct correlation between TOC and gas-bearing capacity was found however, but the structure of TOC variability and the gas-bearing capacity described using variograms is identical. Correlations of the distinguished gas-bearing layers in the wells under consideration suggest a multi-lens or multi-layered reservoir model. The lack of natural boundaries in the shale gas reservoir means that they must be determined arbitrarily based on the assumed marginal gas-bearing capacity. In the case of several gas-bearing zones, numerous variants of interpretation are possible. In any case the low, best and high estimated resources may be evaluated, assigned to each borehole in the area with radii equal to the range of variogram of gas content in horizontal part of the well.

Stem canker and black scurf of potato (Solanum tuberosum L.) caused by Rhizoctonia solani Kühn are important and epidemic diseases in potato-growing regions worldwide, including Iran. In this study, 120 isolates were retrieved from infected stem canker from six potato- growing regions in Iran (Isfahan, Ardebil, Fars, Hamedan, Kurdestan and Kerman). Out of these, 30 isolates were selected as representatives for genetic and virulence analysis. The isolates were analyzed by one sequence analyzes of the ITS-rDNA region, random amplified polymorphic DNA (RAPD) and inter-simple sequence repeat (ISSR), as well as virulence studies. Based on sequence analysis of the ITS-rDNA region, all 30 isolates were assigned to the anastomosis group (AG) and all were assigned to AG-3 PT. Cluster analysis using the unweighted pair group method with the arithmetic averages (UPGMA) method for both RAPD and ISSR markers revealed that they were divided into three main groups, with no correlation to geographical regions of the isolates. Pathogenicity tests showed that all isolates were pathogenic on potato cv. Agria; however, virulence variability was observed among the isolates. The grouping based on RAPD analysis and virulence variability was not correlated.

From the regulatory point of view a strong link between an animal model and human pharmacodynamics of biological drugs is very important to qualify the model as “relevant”. Consistent changes in cell population between human physiology and animal model gain value of this model which then can be pharmacodynamically “relevant” from the regulatory point of view. Consequently, the aim of this study was to determine how similar to human observations is the effect of selected biological drugs on blood cells in a pig model. The study was to carry out a comparative analysis of the variability of selected biochemical and hematological parameters of the blood after administration of five different human therapeutic monoclonal antibodies (mAbs) after a single subcutaneous (SC) dose in breeding pigs. The tested drugs were siltuximab (Syl- vant®), omalizumab (Xolair®), infliximab (Inflectra®), pembrolizumab (Keytruda®), and vedoli- zumab (Entyvio®) given in a single 1 mg/kg SC injection. Each of the tested drugs exerted a sig- nificant effect on at least two of the tested parameters three weeks after the administration. Siltuximab significantly influenced 9 of the analyzed parameters. Vedolizumab significantly influenced 8 of the analyzed parameters. Infliximab had the lowest impact of all the tested drugs, as it significantly influenced only two of the analyzed parameters. The study has proved that the impact of mAbs on the analyzed parameters can be significantly extended over time. This requires the monitoring of hematological parameters in the pig model even many weeks af- ter administration of a drug in a relatively small dose.

The article presents the results of the second part of an eye-tracking study conducted on Polish secondary school students working with a textbook for learning English. 20 dyslexic and 20 non- dyslexic school students worked with two sets of materials that had different graphic layouts but the same content. Their eye movements were recorded. The analysed data show that the arrangement of the material and images on the textbook page influence both the way the students (especially dyslexic ones) work with the book and their results.

APNB (alkaline phenolic no bake), widely known as Alphaset is one of the major sand binder systems used in foundries to make molds and cores without application of heat or gas. This is a two part system comprising of a phenol-formaldehyde resin in alkaline medium as binder and range of esters of dibasic acids and/or polyhydric alcohols as hardeners.

Resin performance varies depending upon formulations. Major variables in formulations are mole ratio of phenol: formaldehyde, total alkali content, ratio of two alkalis (NaOH & KOH) and molecular weight of polymers i.e. chain length.

In present work, one mole ratio of phenol & formaldehyde has been chosen to prepare 8 resins with following details.

Table 1.

Physical and chemical properties of eight (fresh) resins, A to H

Properties of these 8 formulations have been studied for strength and viscosity over a period of 12 weeks in 4 week interval.

Attempt has been made to develop a simple test for simulating hot & retained strength of molds in laboratory. Process followed for chasing hot and retained strength is described under clause 2.

With more and more understanding of the chemistry of alphaset system in last three & half decades it has been possible to identify role of variables contributing towards specific properties vis a vis developing tailor made formulations to fulfill requirements of individual foundries right from mold making to de coring.