TY - JOUR N2 - Biocompatibility, biodegradability and non-toxicity are the main attributes of any material to be used in biomedical applications. Among all the potential stimuli, pH, salt and temperature exist naturally in the internal environment of the human body. Hence internal stimuli responsive hydrogels can be exploited for specific drug delivery and tissue replacement. Poly(vinyl alcohol) (PVA) is the world’s largest volume synthetic polymer, produced for its excellent chemical resistance, physical properties and complete biodegradability, which has resulted in broad practical applications. PVA could be considered a suitable host material due to its good thermo-stability, chemical resistance and film-forming ability. It is also an important material because of its large-scale applications. Novel data analysis techniques were developed to analyze the response of PVA to external stimuli, including temperature and/or pH. The presented non-contact method shows that the PVA polymer gel, physically cross-linked by freezing and thawing, shrinks and swells under the influence of temperature, which is a reversible phenomenon. Under the given conditions, such as temperature, pH and mechanical load, the dominant factor affecting the swelling or contraction of the hydrogel is the change in the temperature of the liquid in which the PVA hydrogel sample is immersed. L1 - http://www.czasopisma.pan.pl/Content/119408/PDF/09_01992_Bpast.No.69(2)_26.04.21_K1_A_SS_OK.pdf L2 - http://www.czasopisma.pan.pl/Content/119408 PY - 2021 IS - 2 EP - e136724 DO - 10.24425/bpasts.2021.136724 KW - PVA KW - hydrogels KW - non-contact method KW - thermal deformation KW - pH-sensitivity A1 - Kazimierska-Drobny, Katarzyna VL - 69 DA - 25.03.2021 T1 - PVA hydrogel deformation in response to change in temperature or pH SP - e136724 UR - http://www.czasopisma.pan.pl/dlibra/publication/edition/119408 T2 - Bulletin of the Polish Academy of Sciences Technical Sciences ER -