TY - JOUR N2 - Since late 2011, porcine infections with highly virulent and antigenic variant of pseudorabies virus (PRV) cause great economic loss in the swine industry in China, and its emergence leads to variable protection efficacy of the commercially available PRV vaccine. In the present study, the potential cross-protective efficacy of two live virus vaccines, includ- ing a commercial vaccine, and an attenuated low pathogenic PRV variant (rPRVTJ-delTK/gE/gI) against a PRV variant Tianjing (TJ) was evaluated in piglets. Vaccination of piglets with the live vaccine Bartha-K61 could not reduce the clinical signs, and was partially efficacious in the reduc- tion of viral loads upon PRV variant TJ challenge, indicating that this live vaccine provided limited cross-protection efficacy against the PRV variant infection. Additionally, rPRVTJ-delTK/gE/gI appeared to exert some beneficial efficiency in shortening the period of clinical fever and improv- ing the growth performance of the challenged pigs. Our findings give a valuable guidance for the choice and use of PRV vaccines to control PRV variant infection in the field. L1 - http://www.czasopisma.pan.pl/Content/113471/PDF/1.pdf L2 - http://www.czasopisma.pan.pl/Content/113471 PY - 2019 IS - No 4 EP - 645 DO - 10.24425/pjvs.2019.129975 KW - pseudorabies virus (PRV) KW - variant TJ KW - live virus vaccines KW - cross-protection A1 - Wang, M. A1 - Wang, L. A1 - Zhao, Q. PB - Polish Academy of Sciences Committee of Veterinary Sciences PB - University of Warmia and Mazury in Olsztyn VL - vol.22 DA - 2019.12.27 T1 - Efficacy evaluation of two live virus vaccines against an emerging pseudorabies virus variant SP - 639 UR - http://www.czasopisma.pan.pl/dlibra/publication/edition/113471 T2 - Polish Journal of Veterinary Sciences ER -