TY - JOUR N2 - Postoperative adhesion (POA) is a common and well-known complication with an estimated risk of 50-100%. The antioxidant effect of n-acetyl-cysteine (NAC) can increase intracellular glutathione levels, thereby reducing adhesion. This study was conducted to compare the outcomes of NAC nanoparticles (Nano-NAC) on intra-abdominal adhesion (IAA) after laparotomy in rat. A total of 25 male Wistar rats were randomized into five groups: 50 mg/kg Nano-NAC, 75 mg/kg Nano-NAC, 150 mg/kg Nano-NAC, NAC and control. During the surgical procedure, some sections (2×2cm) were collected through abdominal midline incision to ensure the infliction of peritoneal damage by a standard adhesion. Macroscopic evaluation was performed on the 14th and 28th day and blood samples were collected to evaluate the inflammatory factor (C-reactive protein) on days 0, 14 and 28. According to the serologic results (CRP test), C-reactive protein was at highest level in 150 mg/kg Nano-NAC and control groups and at lowest level in 50 mg/kg Nano-NAC and 75 mg/kg Nano-NAC groups (p<0.001). The macroscopic evaluation results showed that frequency of adhesion bands was significantly lower in 50 mg/kg Nano-NAC group than the control at the intervals. Results showed that the intraperitoneal administration of lower Nano-NAC dosages (50 and 75 mg/kg) had a major role in the management of postoperative inflammation. Nano-NAC administration was proved feasible, safe and effective in reduction of the C-reactive protein level. L1 - http://www.czasopisma.pan.pl/Content/113463/PDF/18.pdf L2 - http://www.czasopisma.pan.pl/Content/113463 PY - 2019 IS - No 3 EP - 581–588 DO - 10.24425/pjvs.2019.129967 KW - N-acetyl-cysteine nanoparticles KW - intra-abdominal adhesion KW - laparotomy KW - rat A1 - Shahzamani, Sh. A1 - Jahandideh, AR. A1 - Abedi, GhR. A1 - Akbarzadeh, A. A1 - Hesaraki, S. PB - Polish Academy of Sciences Committee of Veterinary Sciences PB - University of Warmia and Mazury in Olsztyn VL - vol.22 DA - 2019.09.24 T1 - Effect of N-acetyl-cysteine nanoparticles on intra-abdominal adhesion after laparotomy in rats SP - 581–588 UR - http://www.czasopisma.pan.pl/dlibra/publication/edition/113463 T2 - Polish Journal of Veterinary Sciences ER -