TY - JOUR N2 - Vaccination is a common routine for prevention and control of human and animal diseases by inducing antibody responses and cell-mediated immunity in the body. Through vaccinations, smallpox and some other diseases have been eradicated in the past few years. The use of a patho- gen itself or a subunit domain of a protein antigen as immunogens lays the basis for traditional vaccine development. But there are more and more newly emerged pathogens which have expe- rienced antigenic drift or shift under antibody selective pressures, rendering vaccine-induced im- munity ineffective. In addition, vaccine development has been hampered due to problems includ- ing difficulties in isolation and culture of certain pathogens and the antibody-dependent enhancement of viral infection (ADE). How to induce strong antibody responses, especially neu- tralizing antibody responses, and robust cell-mediated immune responses is tricky. Here we re- view the progress in vaccine development from traditional vaccine design to reverse vaccinology and structural vaccinology and present with some helpful perspectives on developing novel vac- cines. L1 - http://www.czasopisma.pan.pl/Content/108456/PDF/30.pdf L2 - http://www.czasopisma.pan.pl/Content/108456 PY - 2018 IS - No 3 EP - 643–649 DO - 10.24425/124302 KW - vaccination KW - vaccinology KW - novel vaccine development KW - perspectives A1 - Wang, Y.B. A1 - Wang, L.P. A1 - Li, P. PB - Polish Academy of Sciences Committee of Veterinary Sciences PB - University of Warmia and Mazury in Olsztyn VL - vol. 21 DA - 2018.11.20 T1 - Perspectives on novel vaccine development SP - 643–649 UR - http://www.czasopisma.pan.pl/dlibra/publication/edition/108456 T2 - Polish Journal of Veterinary Sciences ER -