TY - JOUR N2 - Current study was designed to investigate the protective effects of royal jelly on Flunixin me- glumine (FM)-induced spermiotoxicity related to sperm concentration, abnormal spermatozoa count and histopathological changes in mice testis. The subjects were divided into five groups according to FM and/or royal jelly intake: Control group; group 1, FM alone (25 mg/kg, im); group 2, combination of FM (25 mg/kg, im) and royal jelly (200 mg/kg, oral); group 3, FM alone (50 mg/kg, im); and group 4, combination of FM (50 mg/kg, im) and royal jelly (200 mg/kg, oral). The animals were fed once daily for 15 days and they were sacrificed last day. Epididymal sperm concentration and abnormal spermatozoa count were noted. Testicular histological findings were evaluated. On purpose, organization of each animal was graded according to Johnsen’s scoring to assess the spermatogenesis relying on seminiferous tubule cross-section scores. Comparing to controls, FM administration caused a decrease in sperm concentration (p<0.05), an increase in total abnormal spermatozoa rates (p<0.05) and more degenerative changes in testes in mice. Royal jelly supplementation ameliorated both sperm concentration and abnormal spermato- zoa (p<0.05) comparing to the control group. In conclusion, we suggested that royal jelly might have protective effects in the FM-induced reductions in epididymal sperm concentration and in- crease in abnormal spermatozoa rate. L1 - http://www.czasopisma.pan.pl/Content/106896/PDF/11.pdf L2 - http://www.czasopisma.pan.pl/Content/106896 PY - 2018 IS - No 3 EP - 497–506 DO - 10.24425/122624 KW - flunixin meglumine KW - royal jelly KW - male mice KW - sperm KW - testes toxicity A1 - Temamoğulları, F. A1 - Aral, F. A1 - Yılmaz, R. PB - Polish Academy of Sciences Committee of Veterinary Sciences PB - University of Warmia and Mazury in Olsztyn VL - vol. 21 DA - 2018.11.20 T1 - Royal jelly protection on flunixin meglumine-induced spermiotoxicity and testicular degeneration in mice SP - 497–506 UR - http://www.czasopisma.pan.pl/dlibra/publication/edition/106896 T2 - Polish Journal of Veterinary Sciences ER -