@ARTICLE{Sokołowski_Jacek_Impact_2021,
 author={Sokołowski, Jacek and Drozd-Sokołowska, Joanna and Kobylińska, Katarzyna and Biecek, Przemysław and Karakulska-Prystupiuk, Ewa and Tomaszewska, Agnieszka and Gotlib, Tomasz and Niemczyk, Kazimierz and Wiktor-Jędrzejczak, Wiesław and Basak, Grzegorz Władysław},
 volume={Vol. 61},
 number={No 1},
 journal={Folia Medica Cracoviensia},
 pages={109-120},
 howpublished={online},
 year={2021},
 publisher={Oddział PAN w Krakowie; Uniwersytet Jagielloński – Collegium Medicum},
 abstract={Introduction: Screening sinonasal evaluation is routinely performed before allogeneic hematopoietic cell transplantation (allo-HCT), however, data supporting such evaluation is inconsistent. Objectives: Assessment of the utility of screening sinonasal evaluation with computed tomography (CT). Methods: A retrospective analysis of acute leukemia patients who underwent allo-HCT, for whom screening sinonasal CT scans were reevaluated, and for whom Lund-Mackay score (LMS) was calculated. Results: Forty-eight patients, the median age at allo-HCT 38 years (18–58), 52% males, were included. 79% had acute myeloid leukemia (AML), 21% acute lymphoblastic leukemia (ALL). Conditioning inten-sity was myeloablative in 96% of patients, 21% of patients received total body irradiation. 19% of patients had a history of sinusitis before allo-HCT. Screening sinus CT was performed a median of 22 days before allo-HCT. The median LMS was 1 point (0– 10). The severity of sinus abnormalities was: no abnormalities (31%), mild (67%), moderate (2%), severe (0%). Mucosal thickening was the most frequent abnormality (69%). Eleven patients experienced sinusitis after a median of 93 days (11–607) after allo-HCT. 1-year cumulative incidence of sinusitis was 22%. No threshold of LMS and no type of sinus abnormalities were correlated with sinusitis development after allo-HCT. Mild sinus disease at screening did not negatively impact survival in comparison to no sinus disease. Conclusions: Despite the fact, that majority of analyzed patients had either no or mild sinus disease at screening a significant proportion of patients developed sinusitis after allo-HCT. Evaluation of LMS before allo-HCT did not help predict the development of sinusitis after the procedure.},
 type={Article},
 title={Impact of pre-transplantation sinus abnormalities assessed by Lund-Mackay scoring system on sinusitis occurrence after allogeneic hematopoietic cell transplantation in acute leukemia patients},
 URL={http://www.czasopisma.pan.pl/Content/120125/2021-01-FMC-09-Sokolowski.pdf},
 doi={10.24425/fmc.2021.137217},
 keywords={allogeneic hematopoietic cell transplantation, allo-HCT, sinusitis, Lund-Mackay scoring system, computed tomography, screening},
}