The research presented in detail in this scientific paper refers to the modelling of process parameters for natural gas transmission in a centralized system. The method of the factorial experiment was used to model some parameters considered to be vital, namely the gas temperature, the air temperature as well as a certain correction factor on the flow delivered to the population. The study was conducted by accessing information provided by a regulation-measurement station that delivers gas to an important locality in a locality in central Romania. Experimental data collected over 24 hours on a summer day but also on a winter day were used. After a previous study with classical experimental research methods, the factorial experiment was used, which allows the delivery of much more detailed information and the graphical representations are much more precise and detailed, in other words, relevant and useful conclusions can be obtained on objective studied in the research approached.