The paper discusses the feasibility, effectiveness and validity of a gas turbine power plant, operated according to the Brayton comparative cycle in order to develop low-potential waste heat (160◦C) and convert it into electricity. Fourteen working fluids, mainly with organic origin have been examined. It can be concluded that low molecular weight working fluids allow to obtain higher power efficiency of Brayton cycle only if conversions without taking into account internal losses are considered. For the cycle that takes into account the compression conversion efficiency in the compressor and expansion in the gas turbine, the highest efficiency was obtained for the perfluoropentane working medium and other substances with relatively high molecular weight values. However, even for the cycle using internal heat recovery, the thermal efficiency of the Brayton cycle did not exceed 7%.The paper discusses the feasibility, effectiveness and validity of a gas turbine power plant, operated according to the Brayton comparative cycle in order to develop low-potential waste heat (160◦C) and convert it into electricity. Fourteen working fluids, mainly with organic origin have been examined. It can be concluded that low molecular weight working fluids allow to obtain higher power efficiency of Brayton cycle only if conversions without taking into account internal losses are considered. For the cycle that takes into account the compression conversion efficiency in the compressor and expansion in the gas turbine, the highest efficiency was obtained for the perfluoropentane working medium and other substances with relatively high molecular weight values. However, even for the cycle using internal heat recovery, the thermal efficiency of the Brayton cycle did not exceed 7%.