Steroidal saponins isolated from many plant species belonging to Monocotyledones display potent cytotoxic activity towards many human tumor cells. We examined the cytotoxic effects of crude Paris quadrifolia extract for the first time, testing isolated saponin-rich fractions against four different human cell lines using the [(3-(4,5-dimethylthiazol-2-yl)]-2,5-diphenyltetrazolium bromide (MTT) assay. Cytotoxic activity was tested against human promyelocytic leukemia (HL-60) cells, human cervical adenocarcinoma (HeLa) cells and human breast cancer (MDA-MB-468) cells. Human skin fibroblasts were used as non-neoplastic control cells. Our results show significant activity of the weakly water-soluble solid residue and butanolic fraction against HL-60 and HeLa cells. The solid residue exerted cytotoxicity against all tested cell lines.
The paper explains how both Eastern and Western bishops attempted to preserve the doctrine expressed in the Nicene Creed. At the Synod (Council) of Rimini (359) the Latin bishops rejected the Arian concept and accepted the Nicene Creed, they canonically removed the Arian-minded bishops and wrote a letter to the Emperor Constantius. After the Emperor did not approve their attitude, under pressure from his envoys, they changed their mind and adopted a pro-Arian profession of faith. Pro-Arian tendencies also won at the Synod (Council) of Seleucia (359). The staun-chly Arian option won at the Synod (Council) of Constantinople (360). However, the Synod (Council) convoked in Paris by Hilary of Poitiers (361) decidedly rejected the Arian views and approved the Nicene Creed. Consequently, and similarly to the Synod of Sardica (343-344), a split according to language zones became evident: the Greek bishops were in favour of Arianism, and the Latin ones were in favour of the Nicene Creed. It was only at the Council of Constantinople (381) that a definitive sett-lement was achieved – the Nicene concept was adopted according to which the Son is consubstantial with the Father.
The article presents two floating architectural structures developed in response to the needs of local communities. The first one – a river barge “Louise-Catherine” – was adapted in 1929 according to the design of Le Corbusier, one of the most influential architects of the first half of the 20th century, for the purposes of Salvation Army shelter docked on the Seine in Paris and it continued its operation as such until 1994. The second one – Bertha von Suttner state junior high school – was developed in a shipyard to serve as a school, which purpose it has been fulfilling since 1994 while moored on the Danube River in Vienna. The author’s intention was to describe both structures while highlighting common features as well as differences, and to analyse them in view of certain selected aspects. The background for the projects’ development was described account taken of different reasons and circumstances. Issues under analysis include decision making processes in terms of architectural programme, functions and spatial developments. The analysis also includes technical aspects such as structural developments, material and infrastructure – in terms of the floating Viennese school – account taken on safety of using a barge as a school establishment. A separate part of the article is dedicated to the issue of social reception, and incase of the former Salvation Army shelter – actions aimed at the protection of a historic structure.
Post-Versailles Europe saw the emergence of new, quasi-state territorial corporations (enjoying a great deal of autonomy, but not sovereignty). These included the Free State of Fiume/Rijeka (1919- 1924), Free City of Danzig/Gdańsk (1920-1939), Free State of Memel/ Klaipeda (which emerged between 1920 and 1923, before being incorporated into Lithuania with partial autonomy still remaining), as well as, slightly later, the autonomous Åland Islands (1922), and the Republic of Hatay (1938-1939). In theory, those international law constructs were supposed to resolve tensions (including those erupting on the grounds of nationality) between neighbours vying for control over strategic territories (and cities). However, they proved to primarily spark new conflicts of varying length. The article constitutes an attempt at comparing the geneses and development of the first three of the abovementioned “free cities”, as well as identifying their role in the newly-formed League of Nations. In addition, the article attempts to determine the degree to which the principle of national self-determination played a role in the establishment of these entities, as well as the methods used to ensure that the national minorities which found themselves within the borders of these “free cities” were protected.