An aim of this article was to analyze and interpret multifaceted semantic of motives for lying in the novel Women’s Lies by Lyudmila Ulitskaya mainly on the basis of the text’s content as well as related to it preceded annotations, essayistic and journalistic utterances of an actress. We declare that the “laboratory analyze” of women’s lies in its various scenes makes a leading opinion and basic motive of the novel. At the beginning of the conclusion we are concentrating on the author`s definition of lie, so we can later refer to mythological-historical-literary roots. In the context of above mentioned facts, it is interesting that Ulitskaya divides lie on masculine and feminine. Ulitskaya, in her typical way, referring to cultural-religious archetypes and symbols, indicates the roots of masculine lie pertaining even to the Old Testament, as contrary to “pleasant feminine lie”. In this regard, the mythological characters of Odysseus and Penelope are also recognized as representatives. After all, in the content of the analyzed piece are only presented various examples of female lies, and, in our opinion, exposed as an element of the third plane, which unites natural sciences and literature.