Research on acoustical hoods used in industry has been widely discussed; however, the assessment of shape optimization on space-constrained close-fitting acoustic hoods by adjusting design parameters has been neglected. Moreover, the acoustical performance for a one-layer acoustic hood used in a high intensity environment seems to be insufficient. Therefore, an assessment of an optimally shaped acoustical hood with two layers will be proposed. In this paper, a numerical case for depressing the noise level of a piece of equipment by optimally designing a shaped two-layer close-fitting acoustic hood under a constrained space will be introduced. Furthermore, to optimally search for a better designed set for the multi-layer acoustical hood, an artificial immune method (AIM) has been adopted as well. Consequently, this paper provides a quick and effective method to reduce equipment noise by optimally designing a shaped multi-layer close-fitting acoustic hood via the AIM searching technique.