We present the results of a numerical analysis of a two-dimensional photonic crystal with line defect for a laser gas sensor working in a slow light regime. The geometrical parameters of photonic crystals with three different line defects were numerically analyzed: a missing row of holes, a row of holes with changed diameter and air channel. Antireflection sections were also analyzed. The simulations were carried out by MEEP and MPB programs, with the aim to get the values of a group refractive index, transmission and a light-gas overlap as high as possible. The effective refractive index method was used to reduce the simulation time and required computing power. We also described numerical simulation details such as required conditions to work in the slow light regime and the analyzed parameters values’ dependency of the simulation resolution that may influence the accuracy of the results.