This paper presents the design and measurements of low-noise multichannel front-end electronics for recording extra-cellular neuronal signals using microelectrode arrays. The integrated circuit contains 64 readout channels and is fabricated in CMOS 180 nm technology. A single readout channel is built of an AC coupling circuit at the input, a low-noise preamplifier, a band-pass filter and a second amplifier. In order to reduce the number of output lines, the 64 analog signals from readout channels are multiplexed to a single output by an analog multiplexer. The chip is optimized for low noise and good matching performance and has the possibility of pass-band tuning. The low cut-off frequency can be tuned in the 1 Hz - 60 Hz range while the high cut-off frequency can be tuned in the 3.5 kHz - 15 kHz range. For the nominal gain setting at 44 dB and power dissipation per single channel of 220 μW, the equivalent input noise is in the range from 6 μV - 11 μV rms depending on the band-pass filter settings. The chip has good uniformity concerning the spread of its electrical parameters from channel to channel. The spread of the gain calculated as standard deviation to mean value is about 4.4% and the spread of the low cut-off frequency set at 1.6 Hz is only 0.07 Hz. The chip occupies 5×2.3 mm2 of silicon area. To our knowledge, our solution is the first reported multichannel recording system which allows to set in each recording channel the low cut-off frequency within a single Hz with a small spread of this parameter from channel to channel. The first recordings of action potentials from the thalamus of the rat under urethane anesthesia are presented.

Hybrid pixel radiation detectors with a direct photon-to-charge conversion working in a single photon counting mode have gained increasing attention due to their high dynamic range and noiseless imaging. Since sensors of different materials can be attached to readout electronics, they enable work with a wide range of photon energies. The charge-sharing effect observed in segmented devices, such as hybrid pixel detectors, is a phenomenon that deteriorates both spatial resolution and detection efficiency. Algorithms that allow the detection of a photon irrespective of the charge-sharing effect are proposed to overcome these limitations. However, the spatial resolution of the detector can be further improved beyond the resolution determined by the pixel size if information about the charge proportions collected by neighbouring pixels is used to approximate the interaction position. In the article, an approach to achieve a subpixel resolution in a hybrid pixel detector working in the single photon counting mode is described. Requirements and limitations of digital inter-pixel algorithms which can be implemented on-chip are studied. In the simulations, the factors influencing the detector resolution are evaluated, including size of a charge cloud, number of virtual pixel subdivisions, and detector parameters.