1. Agarwal A, Virk G, Ong C, du Plessis SS (2014) Effect of oxidative stress on male reproduction. World J Mens Health 32: 1-17.
2. Angrimani DS, Brito MM, Rui BR, Nichi M, Vannucchi CI (2020) Reproductive and endocrinological effects of Benign Prostatic Hy-perplasia and finasteride therapy in dogs. Sci Rep 10: 14834.
3. Aquino-Cortez A, Pinheiro BQ, Lima DB, Silva HV, Mota-Filho AC, Martins JAM Rodriguez-Villamil P, Moura AA, Silva LD (2017) Proteomic characterization of canine seminal plasma. Theriogenology 95: 178-186.
4. Balercia G, Moretti S, Vignini A, Magagnini M, Mantero F, Boscaro M, Ricciardo-Lamonica G, Mazzanti L (2004) Role of nitric oxide concentrations on human sperm motility. J Androl 25: 245-249.
5. Berry SJ, Strandberg JD, Saunders WJ, Coffey DS (1986) Development of canine benign prostatic hyperplasia with age. Prostate 9: 363-73.
6. Carson C 3rd, Rittmaster R (2003) The role of dihydrotestosterone in benign prostatic hyperplasia. Urology 61 (4 Suppl 1): 2-7.
7. Cochran RC, Ewing LL, Niswender GD (1981) Serum levels of follicle stimulating hormone, luteinizing hormone, prolactin, testos-terone, 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 alpha, 17 beta-diol, 5 alpha-androstane-3 beta, 17 beta-diol, and 17 be-ta-estradiol from male beagles with spontaneous or induced benign prostatic hyperplasia. Invest Urol 19: 142-147.
8. Cunto M, Ballotta G, Zambelli D (2022) Benign prostatic hyperplasia in the dog. Anim Reprod Sci 247: 107096.
9. Dearakhshandeh N, Mogheiseh A, Nazifi S, Ahrari Khafi MS, Abbaszadeh Hasiri M, Golchin-Rad K (2019) Changes in the oxidative stress factors and inflammatory proteins following the treatment of BPH induced dogs with an anti-proliferative agent called tadalafil. J Vet Pharmacol Ther 42: 665–672.
10. Domosławska A, Zduńczyk S, Kankofer M, Bielecka A (2022) Oxidative stress biomarkers in dogs with benign prostatic hyperplasia. Ir Vet J 75: 21.
11. Domosławska A, Zduńczyk S, Niżański W, Janowski T (2013) Assessment of semen quality in infertile dogs using computer-assisted sperm analysis by the Hamilton-Thorne Semen Analyser. Bull Vet Inst Pulawy 57: 429-432.
12. Doshi SB, Khullar K, Sharma RK, Agarwal A (2012) Role of reactive nitrogen species in male infertility. Reprod Biol Endocrinol 10: 109.
13. Fafula RV, Iefremova UP, Onufrovych OK, Maksymyuk HV, Besedina AS, Nakonechnyi IA, Vorobets DZ, Vorobets ZD (2018) Al-terations in Arginase-NO-synthase System of Spermatozoa in Human Subjects with Different Fertility Potential. J Med Biochem 37: 134-140.
14. Ferré-Dolcet L, Frigotto L, Contiero B, Bedin S, Romagnoli S (2022) Prostatic fluid composition and semen quality in dogs with benign prostatic hyperplasia undergoing treatment with osaterone acetate. Reprod Domest Anim 57: 72-79.
15. Flores RB, Angrimani D, Rui BR, Brito MM, Abreu RA, Vannucchi CI (2017) The influence of benign prostatic hyperplasia on sperm morphological features and sperm DNA integrity in dogs. Repro Domest Anim 52 (Suppl 2): 310-315.
16. Fontbonne A (2011) Infertility in male dogs: recent advances. Rev Bras Reprod Anim 35: 266-273.
17. Fraser L, Lecewicz M, Strzeżek J (2002) Fluorometric assessments of viability and mitochondrial status of boar spermatozoa following liquid storage. Pol J Vet Sci 5: 85-92.
18. Garner DL, Johnson LA (1995) Viability assessment of mammalian sperm using SYBR-14 and propidium iodide. Biol Reprod 53: 276–284.
19. Herrero MB, Pérez Martínez S, Viggiano JM, Polak JM, de Gimeno MF (1996) Localization by indirect immunofluorescence of nitric oxide synthase in mouse and human spermatozoa. Reprod Fertil Dev 8:931-934.
20. Krakowski L, Wąchocka A, Brodzki P, Wrona Z, Piech T, Wawron W, Chałabis-Mazurek A (2015) Sperm quality and selected bio-chemical parameters of seminal fluid in dogs with benign prostatic hyperplasia. Anim Reprod Sci 160: 20-125.
21. Lampiao F, Huussen J, du Plessis SS (2014) Effects of nitric oxide exposure on human sperm function and apoptosis markers. Open Reprod Sci J 6: 17-20.
22. Lampiao F, Strijdom H, du Plessis SS (2006) Direct nitric oxide measurement in human spermatozoa: flow cytometric analysis using the fluorescent probe, diaminofluorescein. Int J Androl 29:564-567. DOI: 10.1111/j.1365-2605.2006. 00695.x.
23. Lévy X, Niżański W, von Heimendahl A, Mimouni P (2014) Diagnosis of common prostatic conditions in dogs: an update. Reprod Domest Anim 49 (Suppl 2): 50-57.
24. Linde-Forsberg C (1991) Achieving canine pregnancy by using frozen or chilled extended semen. Vet Clin North Am Small Anim Pract 21: 467-485.
25. Luo Y, Zhu Y, Basang W, Wang X, Li C, Zhou X (2021) Roles of Nitric Oxide in the Regulation of Reproduction: A Review. Front Endocrinol (Lausanne) 12: 52410.
26. Minciullo PL, Inferrera A, Navarra M, Calapai G, Magno C, Gangemi S (2015) Oxidative stress in benign prostatic hyperplasia: a sys-tematic review. Urol Int 94: 249-254.
27. Niżański W, Eberhardt M, Ochota M, Fontaine C, Levy X, Pasikowska J (2022) A Comparative Study of the Effects of Osaterone Ace-tate and Deslorelin Acetate on Sperm Kinematics and Morpho-Functional Parameters in Dogs. Animals (Basel) 12: 1548.
28. Orzołek A, Zasiadczyk Ł, Wysocki P, Kordan W, Krysztofiak P (2018) Relation between nitric oxide (NO) level in semen and certain properties of boar spermatozoa stored at 17°C. Pol J Vet Sci 21: 423-426.
29. Paoli D, Gallo M, Rizzo F, Baldi E, Francavilla S, Lenzi A, Lombardo F, Gandini L (2011) Mitochondrial membrane potential profile and its correlation with increasing sperm motility. Fertil Steril 95: 2315-2319.
30. Polisca A, Troisi A, Fontaine E, Menchetti L, Fontbonne A (2016) A retrospective study of canine prostatic diseases from 2002 to 2009 at the Alfort Veterinary College in France. Theriogenology 85: 835-840.
31. Ramaswamy S, Weinbauer GF (2015) Endocrine control of spermatogenesis: Role of FSH and LH/ testosterone. Spermatogenesis 4: e996025.
32. Rijsselaere T, Van Soom A, Maes D, Verberckmoes S, de Kruif A (2004) Effect of blood admixture on in vitro survival of chilled and frozen-thawed canine spermatozoa. Theriogenology 61: 1589-1602.
33. Rosselli M, Dubey RK, Imthurn B, Macas E, Keller PJ (1995) Effects of nitric oxide on human spermatozoa: evidence that nitric oxide decreases sperm motility and induces sperm toxicity. Hum Reprod 10: 1786-1790.
34. Ruel Y, Barthez PY, Mailles A, Begon D (1998) Ultrasonographic evaluation of the prostate in healthy intact dogs. Vet Radiol Ultra-sound 39: 212-6.
35. Smith J (2008) Canine prostatic disease: a review of anatomy, pathology, diagnosis, and treatment. Theriogenology 70: 375-383.
36. Strzeżek R, Szemplińska K, Filipowicz K, Kordan W (2015) Semen characteristics and selected biochemical markers of canine seminal plasma in various seasons of the year. Pol J Vet Sci 18: 13-18.
37. Thomas CA, Garner DL, DeJarnette JM, Marshall CE (1998) Effect of cryopreservation of bovine sperm organelle function and viability as determined by flow cytometry. Biol Reprod 58: 786-793.
38. Tong Y, Zhou RY (2020) Review of the roles and interaction of androgen and inflammation in benign prostatic hyperplasia. Mediators Inflamm 2020: 7958316.
39. Trzcińska M, Bryła M (2015) Apoptotic-like changes of boar spermatozoa in freezing media supplemented with different antioxidants. Pol J Vet Sci 18: 473-480.
40. Uribe P, Boguen R, Treulen F, Sánchez R, Villegas JV (2015) Peroxynitrite-mediated nitrosative stress decreases motility and mitochon-drial membrane potential in human spermatozoa. Mol Hum Reprod 21: 237-243.
41. Vital P, Castro P, Ittmann M (2016) Oxidative stress promotes benign prostatic hyperplasia. Prostate 76: 58-67.
42. Volpe S, Leoci R, Aiudi G, Lacalandra GM (2009) Relationship between motility and mitochondrial functional status in canine sperma-tozoa. Reprod Domest Anim 44 (Suppl 2): 275-278.

Aitken RJ, Nixon B, Lin M, Koppers AJ, Lee YH, Baker MA (2007) Proteomic changes in mammalian spermatozoa during epididymal mat-uration. Asian J Androl 9: 554-564.

Arroteia KF, Barbieri MF, Souza GH, Tanaka H, Eberlin MN, Hyslop S, Alvares LE, Pereira LA (2014) Albumin is synthesized in epididy-mis and aggregates in a high molecular mass glycoprotein complex involved in sperm-egg fertilization. PLoS One 9: e103566.

Baker MA, Witherdin R, Hetherington L, Cunningham-Smith K, Aitken RJ (2005) Identification of post-translational modifications that occur during sperm maturation using difference in two-dimensional gel electrophoresis. Proteomics 5: 1003-1012.

Bensadoun A, Weinstein D (1976) Assay of proteins in the presence of interfering materials. Anal Biochem 70: 241-250.

Bridges D, Moorhead GB (2005) 14-3-3 proteins: a number of functions for a numbered protein. Sci STKE 2005 (296): re10.

Bustos DM, Iglesias AA (2003) Phosphorylated non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from heterotrophic cells of wheat interacts with 14-3-3 proteins. Plant Physiol 133: 2081-2088.

Candiano G, Bruschi M, Musante L, Santucci L, Ghiggeri GM, Carnemolla B, Orecchia P, Zardi L, Righetti PG (2004) Blue silver: A very sensitive colloidal Coomassie G-250 staining for proteome analysis. Electrophoresis 25: 1327-1333.

Cornwall GA (2009) New insights into epididymal biology and function. Hum Reprod Update 15: 213-227

Cornwall GA (2014) Role of posttranslational protein modifications in epididymal sperm maturation and extracellular quality control, in: Sutovsky, P. (ed.), Posttranslational protein modifications in the reproductive system. Adv Exp Med Biol 759.

Curry E, Safranski TJ, Pratt SL (2011) Differential expression of porcine sperm microRNAs and their association with sperm morphology and motility. Theriogenology 76: 1532-1539.

Dacheux JL, Belleannée C, Jones R, Labas V, Belghazi M, Guyonnet B, Druart X, Gatti JL, Dacheux F. (2009) Mammalian epididymal proteome. Mol Cell Endocrinol 306: 45-50.

de Souza AP, Schorr-Lenz AM, Lucca F, Bustamante-Filho IC (2017) The epididymis and its role on sperm quality and male fertility. Anim Reprod 14: 1234-1244.

Fouchecourt S, Metayer S, Locatelli A, Dacheux F, Dacheux JL (2000) Stallion epididymal fluid proteome: qualitative and quantitative char-acterization; secretion and dynamic changes of major proteins. Biol Reprod 62: 1790-1803.

Fournier-Delpech S, Courot M, Dubois MP (1985) Decreased fertility and motility of spermatozoa from rats immunized with a prealbumin epididymal-specific glycoprotein. J Androl 6: 246-250.

Francou MM, Hombrebueno JR, De Juan J (2012) Identification and cellular location of glutamine synthetase in human sperm. Cell Tissue Res 350: 183-187.

Goncharov T, Niessen K, de Almagro MC, Izrael-Tomasevic A, Fedorova AV, Varfolomeev E Arnott D, Deshayes K, Kirkpatrick DS, Vucic D (2013) OTUB1 modulates c-IAP1 stability to regulate signalling pathways. EMBO J 32: 1103-1114.

Guyonnet B, Dacheux F, Dacheux JL, Gatti JL (2011) The epididymal transcriptome and proteome provide some insights into new epidid-ymal regulations. J Androl 32: 651-664.

Humphreys DT, Carver JA, Easterbrook-Smith SB, Wilson MR (1999) Clusterin has chaperone-like activity similar to that of small heat shock proteins. J Biol Chem 274: 6875-6881.

Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.

Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.

Matt P, Fu.Z, Carrel T, Huso DL, Dirnhofer S, Lefkovits I, Zerkowski HR, Van Eyk JE (2007) Proteomic alterations in heat shock protein 27 and identification of phosphoproteins in ascending aortic aneurysm associated with bicuspid and tricuspid aortic valve. J Mol Cell Cardiol 43: 792-801.

Mohanarao GJ, Atreja SK (2011) Identification of capacitation associated tyrosine phosphoproteins in buffalo (Bubalus bubalis) and cattle spermatozoa. Anim Reprod Sci 123: 40-47.

Moura AA, Souza CE, Stanley BA, Chapman DA, Killian GJ (2010) Proteomics of cauda epididymal fluid from mature Holstein bulls. J Proteomics 73: 2006-2020

Puri P, Acker-Palmer A, Stahler R, Chen Y, Kline D, Vijayaraghavan S (2011) Identification of testis 14-3-3 binding proteins by tandem affinity purification. Spermatogenesis 1: 354-365.

Sawatpanich T, Arun S, Tongpan S, Chaichun A, Sampannang A, Sukhorum W, Maneenin C, Burawat J, Iamsaard S (2018) Localization and changes of tyrosine phosphorylated proteins and ß actin in epididymis of rats treated with valproic acid. Int J Morphol 36: 835-840.

Shisheva A, Sudhof TC, Czech MP (1994) Cloning, characterization and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle. Mol Cell Biol 14: 3459-3468.

Skerget S, Rosenow MA, Petritis K, Karr TL (2015) Sperm proteome maturation in the mouse epididymis. PLoS One 2015 10: e0140650.

Sostaric E, Aalberts M, Gadella BM, Stout TA (2008) The roles of the epididymis and prostasomes in the attainment of fertilizing capacity by stallion sperm. Anim Reprod Sci 107: 237-248.

Tomlins AM, Foxall PJ, Lynch MJ, Parkinson J, Everett JR, Nicholson JK (1998) High resolution 1H NMR spectroscopic studies on dy-namic biochemical processes in incubated human seminal fluid samples. Biochim Biophys Acta 1379: 367-380.

Turner RM (2006) Moving to the beat: a review of mammalian sperm motility regulation Reprod Fertil Dev 18: 25-38.

Wakabayashi H, Matsumoto H, Hashimoto K, Teraguchi S, Takase M, Hayasawa H (1999) Inhibition of iron/ascorbate-induced lipid peroxi-dation by an N-terminal peptide of bovine lactoferrin and its acylated derivatives. Biosci Biotechnol Biochem 63: 955-957.

Yi YJ, Sutovsky M, Kennedy C, Sutovsky P (2012a) Identification of the inorganic pyrophosphate metabolizing, ATP substituting pathway in mammalian spermatozoa. PLoS One 7: e34524.

Yi YJ, Zimmerman SW, Manandhar G, Odhiambo JF, Kennedy C, Jonakova V, Maňásková-Postlerová P, Sutovsky M, Park CS, Sutovsky P (2012b) Ubiquitin-activating enzyme (UBA1) is required for sperm capacitation, acrosomal exocytosis and sperm-egg coat penetration during porcine fertilization. Int J Androl 35: 196-210.

Zhang XG, Hong JY, Yan GJ, Wang YF, Li QW, Hu JH (2015) Association of heat shock protein 70 with motility of frozen-thawed sperm in bulls. Czech J Anim Sci 60: 256-262.