MDAP-2 is a new AMP with high inhibitory activity on Salmonella gallinarum, which may be developed as an antimicrobial agent in the agricultural industry and food preservation. To investigate the underlying the action mechanism of MDAP-2 on Salmonella gallinarum, impacts of MDAP-2 on the growth curve and bacterial morphology of Salmonella gallinarum were studied. iTRAQ-based proteomics analysis was also performed on proteins extracted from treated and untreated Salmonella gallinarum cells. The differentially expressed proteins were then analyzed using the KEGG and GO databases. Finally, the function of some differentially expressed proteins was verified. The results showed that 150 proteins (41 up-regulated and 109 down-regulated) were found differentially expressed (fold > 1.8, p<0.05). The results indi- cate that MDAP-2 kills Salmonella gallinarum mainly through two mechanisms: (i) direct inhibi- tion of cell wall/ membrane/ envelope biogenesis, energy production/ conversion, carbohydrate transport/ metabolism, and DNA transcription/ translation through regulation of special protein levels; (ii) indirect effects on the same pathway through the accumulation of Reactive oxygen species (O2 ▪-, H2O2 and OH▪-).

To explore the basic principles of hierarchical materials designed from nanoscale and up, we have been studying the mechanics of robust and releasable adhesion nanostructures of gecko [1]. On the question of robust adhesion, we have introduced a fractal-like hierarchical hair model to show that structural hierarchy allows the work of adhesion to be exponentially enhanced as the level of structural hierarchy is increased. We show that the nanometer length scale plays an essential role in the bottom-up design and, baring fracture of hairs themselves, a hierarchical hair system can be designed from nanoscale and up to achieve flaw tolerant adhesion at any length scales. For releasable adhesion, we show that elastic anisotropy leads to orientation-dependent adhesion strength. Finite element calculations revealed that a strongly anisotropic attachment pad in contact with a rigid substrate exhibits essentially two levels of adhesion strength depending on the direction of pulling.

Unlike traditional passive filters, modern active filters have the following multiple functions; harmonic filtering, damping, isolation and termination, reactive-power control for power factor correction and voltage regulation, load balancing, voltage-flicker reduction, and/or their combinations. Significant cost reductions in both power semiconductor devices and signal-processing devices have inspired manufactures to put active filters on the market. This paper deals with general pure active filters for power conditioning, and specific hybrid active filters for harmonic filtering of three-phase diode rectifiers, as well as traditional passive filters.

This paper presents a position sensorless drive of non salient pole PM synchronous motors for all speeds including zero speed. Using adaptive Lyapunov design a new approach for the design of an observer is developed. The resulting scheme leads to a nonlinear full order observer for the motor states including the rotor speed. Assuming motor parameters known the design achieves stability with guaranteed region of attraction even at zero speed. The control method is made robust at zero and low speed by changing the direct vector current component to a value different from zero. In order to verify the applicability of the method the controller has been implemented and tested on a 800 W motor.

This study was carried out on the background of Sutong Bridge project based on fracture mechanics, aiming at analyzing the growth mechanism of fatigue cracks of a bridge under the load of vehicles. Stress intensity factor (SIF) can be calculated by various methods. Three steel plates with different kinds of cracks were taken as the samples in this study. With the combination of finite element analysis software ABAQUS and the J integral method, SIF values of the samples were calculated. After that, the extended finite element method in the simulation of fatigue crack growth was introduced, and the simulation of crack growth paths under different external loads was analyzed. At last, we took a partial model from the Sutong Bridge and supposed its two dangerous parts already had fine cracks; then simulative vehicle load was added onto the U-rib to predict crack growth paths using the extended finite element method.

The orientations of recrystallization nuclei and their adjacent as-deformed regions have been characterised in deformed single crystals of different metals (Ag, Cu, Cu-2%wt.Al and Cu-8%wt.Al) in which twinning and/or shear banding occur. {112}<111> oriented crystals of these metals have been compressed to different strains, then lightly annealed, and the crystallographic aspects of the recrystallization process along shear bands examined by local orientation measurement in TEM and SEM. The results clearly show the existence of a well-defined crystallographic relation between the local deformation substructure and the first recrystallized areas of uniform orientation. The first-formed nuclei always exhibit near 25–400(<111>–<112>) type misorientations, in the direction of highest growth, with respect to one of the two main groups of the deformation texture components. The rotation axes can be correlated with the slip plane normal of highest activity. As recrystallization proceeds, recrystallization twinning develops strongly and facilitates rapid growth; the first and higher generations of twins then tend to obscure the initial primary crystallographic relation between the shear bands and recrystallization nuclei .