Abstract
Obesity, which is generally seen in adults, is a serious health problem. Diseases caused by obesity are among the leading causes of death worldwide. Liraglutide (LG) is an analogue of glucagon-like peptide-1, which slows gastrointestinal motility, resulting in decreased food consumption. Gastric plication (GP) and sleeve gastrectomy (SG) is the reduction of stomach volume by surgical means. We examined and compared the body mass index (BMI) changes, metabolic changes and changes in gastric histology in obese rats after LG injection with surgical methods such as SG and GP.
In this research, 35 Wistar Albino female rats were used. Rats were divided into 5 groups with 7 rats in each group. Group (G) 1: The control group, fed with a normal calorie diet for 8 weeks. G 2: Sham group, G 3: SG group, G 4: GP group and G 5: LG group, fed with high-calorie feed for 4 weeks. At the end of the 4th week, the study was terminated by making appropriate interventions for the groups.
When the blood glucose (BG) levels measured at the beginning, 4 th week and 8 th week of the experiment were evaluated, it was monitored that the BG level at the 8 th week was the lowest in the LG group (p<0.05). It was observed that the preop Ghrelin and Leptin levels of the LG group were lower than those of the SG and GP groups (p<0.05). As a consequenc
As a consequence of our metabolic investigations, we observed that the use of LG is at least as effective as SG.
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Bibliography
1. Altunkaynak ME, Ozbek E, Altunkaynak BZ, Can I, Unal D, Unal B (2008) The effects of high-fat diet on the renal structure and mor-phometric parametric of kidneys in rats. J Anat 212: 845-852.
2. Aroda VR, Henry RR, Han J, Huang W, DeYoung MB, Darsow T, Hoogwerf BJ (2012) Efficacy of GLP-1 receptor agonists and DPP-4 inhibitors: meta-analysis and systematic review. Clin Ther 34: 1247-58.
3. Astrup A, Rössner S, Van Gaal L, Rissanen A, Niskanen L, Al Hakim M, Madsen J, Rasmussen MF, Lean ME (2009) Effects of lirag-lutide in the treatment of obesity: a randomised, double-blind, placebo controlled study. Lancet 374: 1606-1616.
4. Borrell LN, Samuel L (2014) Body mass index categories and mortality risk in US adults: the effect of overweight and obesity on ad-vancing death. Am J Public Health 104: 512-519.
5. Brinkman AK (2017) Management of type 1 diabetes. Nurs Clin North Am 52: 499-511.
6. Dag OZ, Dilbaz B (2015) Impact of obesity on infertility in women. J Turk Ger Gynecol Assoc 16: 111-117.
7. Domienik-Karlowicz J, Dzikowska-Diduch O, Lisik W, Chmura A, Pruszczyk P (2015) Short-term cardiometabolic risk reduction after bariatric surgery. Hellenic J Cardiol 56: 61-65.
8. Ewing BT, Thompson MA, Wachtel MS, Frezza EE (2011) A cost-benefit analysis of bariatric surgery on the South Plains region of Texas. Obes Surg 21: 644-649.
9. Gulcicek OB, Ozdogan K, Solmaz A, Yigitbas H, Altınay S, Gunes A, Celik DS, Yavuz E, Celik A, Celebi F (2016) Metabolic and histopathological effects of sleeve gastrectomy and gastric plication: an experimental rodent model. Food Nutr Res 60: 30888.
10. Gunbatar N, Bayiroglu F (2015) The effect of a highly saturated fat diet and ıntermittent fasting diet on experimental colon cancer development and some serum ınflammation markers in rats 1 adiponectin and lipid metabolism. Van Vet J 26: 123-127.
11. Hirth DA, Jones EL, Rothchild KB, Mitchell BC, Schoen JA (2015) Laparoscopic sleeve gastrectomy: long-term weight loss outcomes. Surg Obes Relat Dis 11: 1004-1007.
12. López-Nava BG, Bautista-Castaño I, Jimenez A, de Grado T, Fernandez-Corbelle JP (2015) The Primary Obesity Surgery Endolumenal (POSE) procedure: one-year patient weight loss and safety outcomes. Surg Obes Relat Dis 11: 861-865.
13. Guimarães M, Nora M, Ferreira T, Andrade S, Ribeiro AM, Oliveira V, Carreira MC, Casanueva FF, Monteiro MP (2013) Sleeve gastrectomy and gastric plication in the rat result in weight loss with different endocrine profiles. Obes Surg 23: 710-717.
14. Masarone M, Federico A, Abenavoli L, Loguercio C, Persico M (2014) Non alcoholic fatty liver: epidemiology and natural history. Rev Recent Clin Trials 9: 126-133.
15. Saber SM, Abd El-Rahman HA (2019) Liraglutide treatment effects on rat ovarian and uterine tissues. Reprod Biol 19: 237-244
16. Shi X, Karmali S, Sharma AM, Birch DW (2010) A review of laparoscopic sleeve gastrectomy for morbid obesity. Obes Surg 20: 1171-1177.
17. Sturis J, Gotfredsen CF, Rømer J, Rolin B, Ribel U, Brand CL, Wilken M, Wassermann K, Deacon CF, Carr RD, Knudsen LB (2003) GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics. Br J Pharmacol 140: 123-132.
18. Tadokoro S, Ide S, Tokuyama R, Umeki H, Tatehara S, Kataoka S, Satomura K (2015) Leptin promotes wound healing in the skin. PLoS One 10: e0121242.
19. Talebpour M, Sadid D, Talebpour A, Sharifi A, Davari FV (2017) Comparison of short term effectiveness and postoperative complications: laparoscopic gastric plication vs laparoscopic sleeve gastrectomy. Obes Surg 28: 996-1001.
20. Zhou SJ, Bai L, Lv L, Chen R, Li CJ, Liu XY, Yu DM, Yu P (2014) Liraglutide ameliorates renal injury in streptozotocin induced diabetic rats by activating endothelial nitric oxide synthase activity via the downregulation of the nuclear factor kappaB pathway. Mol Med Rep 10: 2587-2594.
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