Search results

Filters

  • Journals
  • Authors
  • Keywords
  • Date
  • Type

Search results

Number of results: 2
items per page: 25 50 75
Sort by:
Download PDF Download RIS Download Bibtex

Abstract

Purpose: To assess the initial therapy of chronic superficial keratitis (CSK) in dogs with the use of dexamethasone and cyclosporine/ dimethyl sulfoxide combination eye drops.
Methods: The study was conducted on 41 dogs – 16 males and 25 females, aged 2 to 9 years, diagnosed with CSK. The disease was treated with two kinds of eye drops containing 0.1% dexamethasone and 0.75% cyclosporine in combination with 30% DMSO, administered three times a day. Prior to the treatment and after 5 weeks of therapy, depigmentation of the third eyelid margin, corneal neovascularization and pigmentation were assessed. The percentage of the corneal surface afflicted with inflammatory processes was calculated with the use of IsoCalc.com’s Get Area software for CorelDRAW12.
Results: The administered therapy resulted in a significant decrease in the mean number of quadrants affected by corneal neovascularization in the right eye from 2.63 prior to treatment to 0.24 after treatment (p<0.001), and the left eye from 2.66 to 0.59 (p<0.001), respectively. Mean corneal surface afflicted with inflammatory processes was statistically significantly reduced from 53.5% to 26.3% (p<0.001) in the case of right corneas, and from 54.5% to 30.2% (p<0.001) in the case of left corneas. Of 77 corneas diagnosed with pigmentation, pigmentation reduction was observed in 54 and pigmentation increase in 27.
Conclusions: Using dexamethasone and cyclosporine/DMSO combination eye drops proved to be a viable initial therapy against CSK, which facilitates reduction of inflammatory processes and neovascularization atrophy, but in many cases does not inhibit the progress of pigmentation.
Go to article

Bibliography


Balicki I (2005) Research on diagnostic and treatment of chronic superficial keratitis in dogs. Postdoctoral dissertation, WAR Lublin 204: 16-34.
Balicki I (2008) Current methods of diagnosis and therapy of chronic superficial keratitis in dogs. Med Weter 64: 40-44.
Balicki I (2012) Clinical study on the application of tacro- limus and DMSO in the treatment of chronic superficial keratitis in dogs. Pol J Vet Sci 15: 667-676.
Balicki I, Trbolova A (2010) Clinical evaluation of tacrolimus eye drops for chronic superficial keratitis treatment in dogs. Bull Vet Inst Puławy 54: 251-258.
Bigelbach A (1994) Topical use of cyclosporine in the treatment of corticosteroid resistant cases of chronic superficial keratitis (Uberreiter) and plasma cell infiltration of the nictitating membrane. Europ J Comp Anim Pract 38: 271-280.
Binnick SA, Shore SS, Corman A, Fleischmajer R (1977) Failure of dimethyl sulfoxide in the treatment of scleroderma. Arch Dermatol 113: 1398-1402.
Brayton CF (1986) Dimethyl sulfoxide (DMSO): a review. Cornell Vet 76: 61-90.
Chandler HL, Kusewitt DF, Colitz CM (2008) Modulation of matrix metalloproteinases by ultraviolet radiation in the canine cornea. Vet Ophthalmol 11: 135-144.
Del Maestro R, Thaw HH, Björk J, Planker M, Arfors KE (1980) Free radicals as mediators of tissue injury. Acta Physiol Scand Suppl 492: 43-57.
Denk N, Fritsche J, Reese S (2011) The effect of UV-blocking contact lenses as a therapy for canine chronic superficial keratitis. Vet Ophthalmol 14: 186-194.
Jokinen P, Rusanen EM, Kennedy LJ, Lohi H (2011) MHC class II risk haplotype associated with canine chronic superficial keratitis in German Shepherd dogs. Vet Immunol Immunopathol 140: 37-41.
Joseph MA, Kaufman HE, Insler M (2005) Topical tacrolimus ointment for treatment of refractory anterior segment inflammatory disorders. Cornea 24: 417-420.
Kawa P (1997) Research on the influence of agents inhibiting the activity and formation of oxygen free radicals on the healing of an experi-mental corneal ulcer. Doctoral Thesis, AM Lublin, Poland.
Maibach HI, Feldmann RJ (1967) The effect of DMSO on percutaneous penetration of hydrocortisone and testosterone in man. Ann N Y Acad Sci 141: 423-427.
Nell B, Walde I, Billich A, Vit P, Meingassner JG (2005) The effect of topical pimecrolimus on keratoconjunctivitis sicca and chronic superfi-cial keratitis in dogs: results from an exploratory study. Vet Ophthalmol 8: 39-46.
Parrilha LR, Nai GA, Giuffrida R, Barbero RC, Padovani LD, Pereira RH, Silva DA, Silva MC, Diniz MS, Andrade SF (2015) Comparison of 1% cyclosporine eye drops in olive oil and in linseed oil to treat experimentally-induced keratoconjunctivitis sicca in rabbits. Arq Bras Oftalmol 78: 295-299.
Rawls WF, Cox L, Rovner ES (2017) Dimethyl sulfoxide (DMSO) as intravesical therapy for interstitial cystitis/bladder pain syndrome: A review. Neurourol Urodyn 36: 1677-1684.
Sanchez RF, Dawson C, Matas Riera M, Escanilla N (2016) Preliminary results of a prospective study of inter- and intra-user variability of the Royal Veterinary College corneal clarity score (RVC-CCS) for use in veterinary practice. Vet Ophthalmol 19: 313-318.
Sanchez S, Studer M, Currin P, Barlett P, Bounous D (2001) Listeria keratitis in a horse. Vet Ophthalmol 4: 217-219.
Slatter DH, Lavach JD, Severin GA, Young S (1977) Uberreteiter’s syndrome (chronic superficial keratitis) in dogs in the Rocky Mountain area – a study of 463 cases. J Small Anim Pract 18: 757-772.
Toczołowski J, Wolski T, Klamut-Sory K (1992) Effect of drugs inhibiting the formation of hydroxide radicals on healing of experimental corneal ulcer. Klin Oczna 94: 83-85.
Williams DL (1997) A comparative approach to topical cyclosporine therapy. Eye (Lond) 11: 453-464.
Williams DL (2005) Major histocompatibility class II expression in the normal canine cornea and in canine chronic superficial keratitis. Vet Ophthalmol 8: 395-400.
Williams DL, Hoey AJ, Smitherman P (1995) Comparison of topical cyclosporin and dexamethasone for the treatment of chronic superficial keratitis in dogs. Vet Rec 137: 635-639.
Go to article

Authors and Affiliations

I. Balicki
1
M. Szadkowski
1
A. Balicka
2
J. Zwolska
1

  1. Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Poland
  2. Small Animal Clinic, University of Veterinary Medicine and Pharmacy in Košice, Slovakia
Download PDF Download RIS Download Bibtex

Abstract

Koncepcję Boga Orygenesa należy analizować w kontekście filozofii neoplatońskiej. Zgodnie z nauczaniem neoplatońskim Orygenes przedstawiał Boga jako niematerialną, niezmienną i niepodzielną Jednię, która jest źródłem istnienia wszystkich bytów. Nawiązując do neoplatonizmu twierdził, że boskość i doskonałość bytów zmniejsza się wraz z oddalaniem się ich od źródła bytu, czyli Boga. Również Syn Boży ma w sobie mniej boskości i doskonałości od Boga Ojca, będąc Bogiem w sensie wtórnym.

Go to article

Authors and Affiliations

Rafał Marcin Leszczyński

This page uses 'cookies'. Learn more