Abstract
Gallbladder mucocele (GM) is a common extrahepatic biliary disease recognized in dogs and is defined as the expansion and extension of the gallbladder by an accumulation of semi-solid bile or bile acid. Histopathological diagnosis of necrotizing cholecystitis and transmural coagulative necrosis of the gallbladder wall shows poor prognosis. Conversely, histopathological diagnosis with partial necrotic findings is often achieved. We hypothesized that histopathological partial necrosis of the gallbladder wall is the primary lesion of necrotic cholecystitis or transmural ischemic necrosis. Therefore, we investigated the relationship between histopathological necrosis/ partial necrosis findings and their clinical conditions. We retrospectively analyzed 55 dogs diagnosed with GM that had undergone cholecystectomy at the Yamaguchi University Animal Medical Center. The group with histopathological necrosis/partial necrosis of the gallbladder wall showed elevated levels of preoperative white blood cells, alanine transaminase, alkaline phosphatase, γ-glutamyltransferase, total bilirubin, and C-reactive protein compared to the non-necrotic group. Partial necrosis of the gallbladder wall may affect the progression of the disease and hematological abnormalities. Additionally, all death cases until 2 weeks were included in the histopathological necrosis/partial necrosis group. In this study, we found that poor prognosis factors were associated with partial necrosis of the gallbladder wall. Furthermore, these cases of partial necrosis showed elevated levels of blood test parameters. These results suggest that necrosis of the gallbladder wall is associated with poor prognosis and poor pathophysiological conditions.
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Bibliography
Aguirre AL, Center SA, Randolph JF, Yeager AE, Keegan AM, Harvey HJ, Erb HN (2007) Gallbladder disease in Shetland Sheepdogs: 38 cases (1995-2005). J Am Vet Med Assoc 231: 79-88.
Amsellem PM, Seim HB, 3rd, MacPhail CM, Bright RM, Twedt DC, Wrigley RH, Monnet E (2006) Long-term survival and risk factors associated with biliary surgery in dogs: 34 cases (1994-2004). J Am Vet Med Assoc 229: 1451-1457.
Bennett GL, Rusinek H, Lisi V, Israel GM, Krinsky GA, Slywotzky CM, Megibow A (2002) CT findings in acute gangrenous cholecystitis. AJR Am J Roentgenol 178: 275-281.
Besso JG, Wrigley RH, Gliatto JM, Webster CR (2000) Ultrasonographic appearance and clinical findings in 14 dogs with gallbladder muco-cele. Vet Radiol Ultrasound 41: 261-271.
Bingener J, Stefanidis D, Richards ML, Schwesinger WH, Sirinek KR (2005) Early conversion for gangrenous chole- cystitis: impact on outcome. Surg Endosc 19: 1139-1141.
Borusewicz P, Jankowski M, Glińska-Suchocka K, Kubiak K, Spużak J, Bieżyński J, Bąkowska J, Kubiak D, (2016) Diagnosis and treatment of gallbladder mucocele in dogs. Medycyna weterynaryjna 72: 175-179.
Center SA (2009) Diseases of the gallbladder and biliary tree. Vet Clin North Am Small Anim Pract 39: 543-598.
Chaudhry S, Hussain R, Rajasundaram R, Corless D (2011) Gangrenous cholecystitis in an asymptomatic patient found during an elective laparoscopic cholecystectomy: a case report. J Med Case Rep 5: 199.
Choi J, Kim A, Keh S, Oh J, Kim H, Yoon J (2014) Comparison between ultrasonographic and clinical findings in 43 dogs with gallbladder mucoceles. Vet Radiol Ultrasound 55: 202-207.
Contini S, Corradi D, Busi N, Alessandri L, Pezzarossa A, Scarpignato C (2004) Can gangrenous cholecystitis be prevented?: a plea against a “wait and see” attitude. J Clin Gastroenterol 38: 710-716.
Fagan SP, Awad SS, Rahwan K, Hira K, Aoki N, Itani KM, Berger DH (2003) Prognostic factors for the development of gangrenous chole-cystitis. Am J Surg 186: 481-485.
Friedman GD (1993) Natural history of asymptomatic and symptomatic gallstones. Am J Surg 165: 399-404.
Fry DE, Cox RA, Harbrecht PJ (1981) Gangrene of the gallbladder: a complication of acute cholecystitis. South Med J 74: 666-668.
Holt DE, Mehler S, Mayhew PD, Hendrick MJ (2004) Canine gallbladder infarction: 12 cases (1993-2003). Vet Pathol 41: 416-418.
Kovatch RM, Hildebrandt PK, Marcus LC (1965) Cystic mucinous hypertrophy of the mucosa of the gall bladder in the dog. Pathol Vet 2: 574-584.
Malek S, Sinclair E, Hosgood G, Moens NM, Baily T, Boston SE (2013) Clinical findings and prognostic factors for dogs undergoing chol-ecystectomy for gall bladder mucocele. Vet Surg 42: 418-426.
Mealey KL, Minch JD, White SN, Snekvik KR, Mattoon JS (2010) An insertion mutation in ABCB4 is associated with gallbladder mucocele formation in dogs. Comp Hepatol 9: 6.
Mesich ML, Mayhew PD, Paek M, Holt DE, Brown DC (2009) Gall bladder mucoceles and their association with endocrinopathies in dogs: a retrospective case-control study. J Small Anim Pract 50: 630-635.
Morfin E, Ponka JL, Brush BE (1968) Gangrenous cholecystitis. Arch Surg 96: 567-573.
Newell SM, Selcer BA, Mahaffey MB, Gray ML, Jameson PH, Cornelius LM, Downs MO (1995) Gallbladder mucocele causing biliary obstruction in two dogs: ultrasonographic, scintigraphic, and pathological findings. J Am Anim Hosp Assoc 31: 467-472.
Nikfarjam M, Niumsawatt V, Sethu A, Fink MA, Muralidharan V, Starkey G, Jones RM, Christophi C (2011) Outcomes of contemporary management of gangrenous and non-gangrenous acute cholecystitis. HPB (Oxford) 13: 551-558.
Norwich A (2011) Gallbladder mucocele in a 12-year-old cocker spaniel. Can Vet J 52: 319-321.
Pike FS, Berg J, King NW, Penninck DG, Webster CR (2004) Gallbladder mucocele in dogs: 30 cases (2000-2002). J Am Vet Med Assoc 224: 1615-1622.
Smalle TM, Cahalane AK, Koster LS (2015) Gallbladder mucocoele: A review. J S Afr Vet Assoc 86: 1318.
Tsukagoshi T, Ohno K, Tsukamoto A, Fukushima K, Takahashi M, Nakashima K, Fujino Y, Tsujimoto H (2012) Decreased gallbladder emptying in dogs with biliary sludge or gallbladder mucocele. Vet Radiol Ultrasound 53: 84-91.
Uno T, Okamoto K, Onaka T, Fujita K, Yamamura H, Sakai T (2009) Correlation between ultrasonographic imaging of the gallbladder and gallbladder content in eleven cholecystectomised dogs and their prognoses. J Vet Med Sci 71: 1295-1300.
Walter R, Dunn ME, d’Anjou MA, Lecuyer M (2008) Nonsurgical resolution of gallbladder mucocele in two dogs. J Am Vet Med Assoc 232: 1688-1693.
Worley DR, Hottinger HA, Lawrence HJ (2004) Surgical management of gallbladder mucoceles in dogs: 22 cases (1999-2003). J Am Vet Med Assoc 225: 1418-1422.
Xenoulis PG (2014) The association between hyperlipidemia and gall bladder mucoceles in dogs. Vet J 200: 353-354.
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