One of the most important natural phenomena that causes harmful damage around the world is the occurrence of sudden and severe floods. There are various solutions to deal with floods. Among the structural measures of flood risk management, we can mention the construction of levee, detention basin, channel modification, and a combination of the mentioned measures. Manafwa is a flood-prone area in Uganda currently protected by a 6.6 m high levee. Unfortunately, the existing levee does not have ideal performance, and the probability of failure is very high. Therefore, the main purpose of this study is to compare seven flood management measures in the flood-prone area of Manafwa and to select the best flood risk management proposal. These management measures are: 1) construction of a levee with a height of 6.5 m, 2) construction of a levee with a height of 7 m, 3) construction of a levee with a height of 7.5 m, 4) construction of a levee with a height of 8 m, 5) channel modification, 6) detention basin and 7) a combination of structural measures of channel modification and detention basin. The results show that although building a levee with a height of 8 m is more expensive than other options, but it reduces the expected annual flood damage to about USD30.5 thous.