Abstract
Porcine epidemic diarrhea (PED) is a disease extremely harmful to pig health. Intramuscular and Houhai acupoint injections are the main immunization routes to prevent and control PED. This study aimed to evaluate the efficacy of these two routes in pregnant sows based on serum IgG, IgA, and neutralizing antibody levels. PED virus (PEDV) immunoprophylaxis with live-attenuated and inactivated vaccines was administered. The vaccinations for the intramuscular injections elevated IgG and neutralizing antibody levels more than Houhai acupoint injections at most timepoints after immunization. However, the anti-PEDV IgA antibodies induced by vaccination with the two immunization routes did not differ significantly. In conclusion, intramuscular injections are better than Houhai acupoint injections for PEDV vaccination of pregnant sows.
Go to article
Bibliography
1. Brown J, Poonsuk K, Cheng TY, Rademacher C, Kalkwarf E, Tian L, McKeen LA, Wang C, Gimenez-Lirola L, Baum D, Karriker LA (2023) Comparison of two diagnostic assays for the detection of serum neutralizing antibody to porcine epidemic diarrhea virus. Animals (Basel) 13:757.
2. Hsueh FC, Chang YC, Kao CF, Hsu CW, Chang HW (2020) Intramuscular immunization with chemokine-adjuvanted inactive porcine epidemic diarrhea virus induces substantial protection in pigs. Vaccines (Basel) 8:102.
3. Jin H, Wu Y, Bi S, Xu Y, Shi F, Li X, Ma X, Hu S (2020) Higher immune response induced by vaccination in Houhai acupoint relates to the lymphatic drainage of the injection site. Res Vet Sci 130: 230-236.
4. Jung K, Saif LJ, Wang Q (2020) Porcine epidemic diarrhea virus (PEDV): An update on etiology, transmission, pathogenesis, and pre-vention and control. Virus Res 286: 198045.
5. Krishna VD, Kim Y, Yang M, Vannucci F, Molitor T, Torremorell M, Cheeran MC (2020) Immune responses to porcine epidemic diar-rhea virus (PEDV) in swine and protection against subsequent infection. PLoS One 15: e0231723.
6. Langel SN, Paim FC, Alhamo MA, Buckley A, Van Geelen A, Lager KM, Vlasova AN, Saif LJ (2019) Stage of gestation at porcine epidemic diarrhea virus infection of pregnant swine impacts maternal immunity and lactogenic immune protection of neonatal suckling piglets. Front Immunol 10: 727.
7. Lee C (2015) Porcine epidemic diarrhea virus: an emerging and re-emerging epizootic swine virus. Virol J 12: 193.
8. Lv C, Xiao Y, Li X, Tian K (2016) Porcine epidemic diarrhea virus: current insights. Virus Adapt Treat 8: 1-12.
9. Shibata I, Tsuda T, Mori M, Ono M, Sueyoshi M, Uruno K (2000) Isolation of porcine epidemic diarrhea virus in porcine cell cultures and experimental infection of pigs of different ages. Vet Microbiol 72: 173-182.
10. Sun D, Wang X, Wei S, Chen J, Feng L (2016) Epidemiology and vaccine of porcine epidemic diarrhea virus in China: a mini-review. J Vet Med Sci 78: 355-363.
11. Xu W, Hu S (2021) Administration of infectious bursal disease vaccine in Houhai acupoint promotes robust immune responses in chickens. Res Vet Sci 142: 149-153.
Go to article
en
pl
