To prepare a high-quality asymmetrical bending pipe of aluminum alloy by casting, the parting surfaces of the asymmetrical parts were determined based on the characteristics of the parts. Also, the forming process was designed and calculated. After that, the different types of gating systems were designed and the casting process was calculated by ProCAST, and then the influence of different casting gating systems on asymmetrical bending pipes was analyzed. The simulation results show that in the solidification process, although the filling speed of the single runner was slow, but the filling was stable. The gating system with a single runner-round flange filling system would lead to being more uniform for filling flow field and be sequential solidification of temperature field distribution, and stronger of the feeding ability. During the solidification process, the solid phase ratio of the single runner-round flange casting system is larger, and the shrinkage volume is smaller, which made the quality of castings better. Finally, a metal mold and core were made to cast a perfect asymmetric bending pipe of aluminum alloy product in a die casting machine. So the single runner-round flange filling system is suitable for asymmetrical bending pipe casting.