The aim of the research was to evaluate effects of different rootstocks and management practices to counteracting replant disease in an apple orchard. The experiment was conducted in the Experimental Orchard of the National Institute of Horticultural Research in Dąbrowice, Poland, in 2014–2020. Apple trees of the cultivar ‘Ligolina’ were planted in autumn of 2013 at spacing of 3.8 × 1.4 m in the rows of an apple orchard that had been grubbed up in spring. The following experimental setups were used: (i) two types of rootstocks of different growth vigour (M.9, P14); (ii) replacement of soil in rows of trees with virgin soil; (iii) fertigation with ammonium phosphate; (iv) control (cultivation in the exhausted soil). Replantation significantly limited the growth of apple trees by reducing the cross- sectional area of the tree trunk, and the number and length of annual shoots. Fruit yields of apple trees grown on the replantation site were significantly lower than those of the trees grown in virgin soil. The use of ammonium phosphate fertigation had a positive effect on the growth and yield on the replantation site, especially when it was combined with the use of a stronger-growing rootstock (P14). The most effective environmentally friendly method of eliminating the apple replant disease is the replacement of the exhausted soil with virgin soil, i.e. soil that has not been used for growing fruit trees before.