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Abstract

Chemical and process engineering offers scientific tools for solving problems in the biomedical field, including drug delivery systems. This paper presents examples of analyzing the dynamics of dispersed systems (aerosols) in medical inhalers to establish a better relationship between the test evaluation results of these devices and the actual delivery of drugs to the lungs. This relationship is referred to as in vitro-in vivo correlation (IVIVC). It has been shown that in dry powder inhalers (DPls), the aerosolization process and drug release times are determined by the inhalation profile produced by the patient. It has also been shown that inspiratory flow affects the size distribution of aerosols generated in other inhalation devices (vibrating mesh nebulizers, VMNs), which is due to the evaporation of droplets after the aerosol is mixed witha dditional air taken in by the patient. The effects demonstrated in this work are overlooked in standard inhaler testing methods, leading to inaccurate information about the health benefits of aerosol therapy, thus limiting the development of improved drug delivery systems.
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Authors and Affiliations

Agata Dorosz
1
ORCID: ORCID
Arkadiusz Moskal
1
ORCID: ORCID
Tomasz R. Sosnowski
1
ORCID: ORCID

  1. Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warsaw, Poland
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Abstract

The works presents the application of mass/volume balances of liquid drug converted into the aerosol during atomization in medical nebulizers. The amount of liquid that can be delivered to the respiratory system during inhalation is reduced compared to the nominal dose not only because of drug losses both in the device (the residual volume, RV) and outside the nebulizer (in the mouthpiece, mask, or tubings), but also to the limitations of the patient (periodic flow with limited capacity). The paper should help to understand the complexity of aerosol therapy widely used in asthma, COPD and other pulmonary diseases.
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Bibliography

Ari A., 2014. Jet, ultrasonic, and mesh nebulizers: An evaluation of nebulizers for better clinical outcomes. Eurasian J. Pulmonol. 16, 1–7. DOI: 10.5152/ejp.2014.00087.
Chang K.H., Moon S.-H., Oh J.Y., Yoon Y-S., Gu N., Lim C.-Y., Park B.J., Nam K.C., 2019. Comparison of salbutamol delivery efficiency for jet versus mesh nebulizer using mice. Pharmaceutics, 11, 192. DOI: 10.3390/pharmaceutics11040192.
Dobrowolska K., Sosnowski T.R., 2020. Evolution of droplet size distribution in selected nebulizers. Physicochem. Probl. Miner. Process., 56, 32–40. DOI: 10.37190/ppmp/126312.
Elphick M., von Hollen D., Pritchard J.N., Nikander K., Hardaker L.E., Hatley R.H.M., 2015. Factors to consider when selecting a nebulizer for a new inhaled drug product development program. Expert Opin. Drug Delivery, 12, 1375–1387. DOI: 10.1517/17425247.2015.1014339.
Emeryk A., Pirozynski M., Mazurek H., Janeczek K., Sosnowski T.R., Kuna P., 2020. The position of Polish experts regarding nebulization during the COVID-19 pandemic. Terapia 4 (387), 12–18 (in Polish).
Fink J.B., Ehrmann S., Li J., Dailey P., McKiernan P., Darquenne C., Martin A.R.,Rothen-Rutishauser B.,Kuehl P.J., Häussermann S., MacLoughlin R., Smaldone G.C., Muellinger B., Corcoran T.E., Dhand R., 2020. Reducing aerosol-related risk of transmission in the era of COVID-19: an interim guidance endorsed by the International Society of Aerosols in Medicine. J. Aerosol Med. Pulm. Drug Delivery, 33, 300–304. DOI: 10.1089/jamp.2020.1615.
MacLoughlin R.J., Higgins B.D., Laffey J.G., O’Brien T., 2009. Optimized aerosol delivery to a mechanically ventilated rodent. J. Aerosol Med. Pulm. Drug Delivery, 22, 323–332. DOI: 10.1089/jamp.2008.0717.
Niven R.W., 1996. Atomization and nebulizers. In: Hickey A.J. (Ed.), Inhalation aerosols. Physical and biological basis for therapy. Marcel Dekker Inc., New York.
Pirozynski M., Florkiewicz E., Radzikowski K., Sosnowski T.R., 2015. Practical aspecst of nebulization in adults, including dosing pricnciples for drug aerosols. In: Pirozynski M. (Ed.), ABC of nebulization inlcuding dosing principles. Via Medica, Gdansk, 144–186 (in Polish).
Pirozynski M., Sosnowski T.R., 2016. Inhalation devices: from basic science to practical use, innovative vs generic products. Expert Opin. Drug Delivery, 13, 1559–1571. DOI: 10.1080/17425247.2016.1198774.
Sosnowski T.R., 2019. Critical assessment of the quantitative criteria used in the comparison of nebulizers. EC Pulm. Respir. Med., 8(9), 656–662.
Sosnowski T.R., 2020. Inhalation as a means of systemic drug delivery, In: Lai W.F. (Ed.), Systemic delivery technologies in anti-aging medicine: Methods and applications. Healthy ageing and longevity. Springer, Cham, 327–344. DOI: 10.1007/978-3-030-54490-4_12.
Sosnowski T.R., Kramek-Romanowska K., 2016. Predicted deposition of e-cigarette aerosol in the human lungs. J. Aerosol Med. Pulm. Drug Delivery, 29, 299–309. DOI: 10.1089/jamp.2015.1268.
Sosnowski T.R., Odziomek M., 2019. Inhalable steroids delivered from mesh nebulizers – what should we know? Terapia 4(375), 83–88 (in Polish).
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Authors and Affiliations

Tomasz R. Sosnowski
1
ORCID: ORCID
Kamil Janeczek
2
Karolina Grzywna
3 4
Andrzej Emeryk
2

  1. Warsaw University of Technology, Faculty of Chemical and Process Engineering, Warynskiego 1, 00-645 Warsaw, Poland
  2. Medical University of Lublin, Clinics of Lung Diseases and Pediatric Reumathology, Gebali 6, 20-093 Lublin, Poland
  3. Silesian Medical University in Katowice, Student Scientific Club at the Chair and Division of Pathomorphology and Molecular Diagnostics, Medyków 18, 40-752 Katowice, Poland
  4. Silesian Medical University in Katowice, Faculty of Medical Sciences in Zabrze, Traugutta sq. 2, 41-800 Zabrze, Poland

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