This paper presents the results of an experimental study and
mathematical modeling of the effect of dynamic instabilities on the condensation phase transformation of the refrigerants homogeneous R134a and its replacement in the form of isomers R1234yf and R1234ze and R404A or R507 and R448A in pipe mini-channels. In the case of homogeneous chlorofluorocarbons (CFCs), it is the 1234 isomers that are envisioned as substitutes for the withdrawn ones with high ozone depletion potential and global warming potential. For zeotropic and azeotropic mixtures, for example, these are R507 or R448A. The paper presents a dimensional analysis procedure based on the Buckingham Π theorem to develop a regression velocity model of pressure dynamic instabilities. The experimental part of the work was carried out with the use of tubular mini-channels with internal diameter 1.40–3.3 mm.