Starting from consideration that urban intersections are sites with promise for safety and operational improvements, the paper describes the steps taken to develop a crash predictive model for estimating the safety performance of urban unsignalized intersections located in Palermo, Italy. The focus is on unsignalized four-legged one-way intersections widespread in Italian downtowns. The sample considered in the study consist of 92 intersections in Palermo, Italy. For the study were collected crashes occurred in the sites during the years 2006‒2012, geometric design and functional characteristics and traffic flow. Results showed that data were overdispersed and NB1 distributed. In order to account for the correlation within responses Generalized Estimating Equations (GEE) were used under different working correlation matrices.