The paper presents optimization of 5-rod (5-link) suspension mechanism used in passenger cars for independent guiding of the wheels. Selected stiffness coefficients defined for five elastomeric bushings installed in joints of the suspension rods are considered as design variables. Two models with lumped parameters (i.e. elastokinematic and dynamic) of wheel-suspension-car body system are formulated to describe relationships between the design variables and the performance indexes including car active safety and ride comfort, respectively. The multi-criteria goal function is minimized using a deterministic algorithm. The suspension with optimized bushings rates fulfils desired elastokinematic criteria together with a defined dynamic criterion, describing the so-called rolling comfort. An event of car passing over short road bump is considered as dynamic conditions. The numerical example deals with an actual middle-class passenger car with 5-rod suspension at the front driven axle. Estimation of the models parameters and their verification were carried out on the basis of indoor and outdoor experiments. The proposed optimization procedure can be used to improve the suspension design or development cycle.