It is nearly impossible to study behaviour effectively without any reference to its context. This is because it is generally known in the psychological literature that behaviour is partially a product of its environment. This suggests that many behavioural processes may be universal but there are significant variations in their manifestations. For instance, love may be a universal process but its manifestation varies from one society to another. Given that ethical decision-making is a behavioural process, it stands to reason that its manifestation will vary from one culture to another. It is against this premise that this paper seeks to demonstrate that despite the existence of the ‘universal’ normative ethical principles, ethical decisions will be expected to vary across cultural space and even evolve with time. This paper achieves this objective by employing typical ethical dilemmas that Ghanaian psychologists and other health professionals encounter to show how and why what is ethical in one culture becomes unethical in the Ghanaian context and what is unethical in the Ghanaian context becomes ethical in another culture.