TY - JOUR N2 - Canine parvovirus (CPV) causes acute gastroenteritis in domestic dogs, cats, and several wild carnivore species. In this study, the full-length VP2 gene of 36 CPV isolates from dogs and cats infected between 2016 and 2017 in Beijing was sequenced and analyzed. The results showed that, in dogs, the new CPV-2a strain was the predominant variant (n = 18; 50%), followed by the new CPV-2b (n = 6; 16.7%) and CPV-2c (n = 3; 8.3%) strains, whereas, among cats, the predominant strain was still CPV-2 (n = 9; 25%). One new CPV-2a strain, 20170320-BJ-11, and two CPV-2c strains, 20160810-BJ-81 and 20170322-BJ-26, were isolated and used to perform experimental infections. Multiple organs of beagles that died tested PCR positive for CPV, and characteristic histopathological lesions were observed in organs, including the liver, spleen, lungs, kidneys, small intestines, and lymph nodes. Experimental infections showed that the isolates from the epidemic caused high morbidity in beagles, indicating their virulence in animals and suggesting the need to further monitor evolution of CPV in China. L1 - http://www.czasopisma.pan.pl/Content/112766/PDF/13.pdf L2 - http://www.czasopisma.pan.pl/Content/112766 PY - 2019 IS - No 2 EP - 287–296 DO - 10.24425/pjvs.2019.129219 KW - canine parvovirus KW - molecular epidemiology KW - phylogenetic analysis KW - pathogenesis A1 - Chen, M.R. A1 - Guo, X.Y. A1 - Wang, Z.Y. A1 - Jiang, Y.T. A1 - Yuan, W.F. A1 - Xin, T. A1 - Hou, S.H. A1 - Song, T.Q. A1 - Lin, W.D. A1 - Zhu, H.F. A1 - Jia, H. PB - Polish Academy of Sciences Committee of Veterinary Sciences PB - University of Warmia and Mazury in Olsztyn VL - vol.22 DA - 2019.07.01 T1 - Isolation and sequence analysis of the complete VP2 gene of canine parvovirus from Chinese domestic pets and determination of the pathogenesis of these circulating strains in beagles SP - 287–296 UR - http://www.czasopisma.pan.pl/dlibra/publication/edition/112766 T2 - Polish Journal of Veterinary Sciences ER -