TY - JOUR N2 - The purpose of the study was to assess the effect of autologous activated platelet-rich plasma on healing of a bone substitute - tricalcium phosphate hydroxyapatite in experimental long bone defects using an animal model. The experiment involved an animal model of femoral defect. 24 Termond white rabbits were used in the study. We evaluated the effect of autologous platelet-rich plasma on tricalcium phos- phate using classical radiology, micro-CT studies, strength tests and histological evaluation. Radiological and histological assessment did not show a beneficial effect of PRP together with a bone substitute in comparison to filling the defects only with bone replacement material. The only benefit of adding platelet-rich plasma to a bone substitute was shown in microCT imaging. Autologous, activated platelet-rich plasma combined with hydroxyapatite tricalcium phos- phate has a positive effect on the remodeling of the newly formed bone tissue, increasing its density. L1 - http://www.czasopisma.pan.pl/Content/110892/PDF/07.pdf L2 - http://www.czasopisma.pan.pl/Content/110892 PY - 2019 IS - No 2 EP - 243–250 DO - 10.24425/pjvs.2019.127092 KW - platelet-rich plasma KW - hydroxyapatite tricalcium phosphate KW - bone regeneration KW - bone defects KW - rabbit model A1 - Skwarcz, S. A1 - Bryzek, I. A1 - Gregosiewicz, A. A1 - Warda, E. A1 - Gawęda, K. A1 - Tarczyńska, M. A1 - Skwarcz, J. A1 - Nadulski, R. A1 - Starek, A. A1 - Sanford, J. PB - Polish Academy of Sciences Committee of Veterinary Sciences PB - University of Warmia and Mazury in Olsztyn VL - vol.22 DA - 2019.07.01 T1 - The effect of activated platelet-rich plasma (PRP) on tricalcium hydroxyapatite phosphate healing in experimental, partial defects of long bone shafts in animal models SP - 243–250 UR - http://www.czasopisma.pan.pl/dlibra/publication/edition/110892 T2 - Polish Journal of Veterinary Sciences ER -