TY - JOUR N2 - Introduction: Platelet-rich plasma (PRP) preparations can be used in bone tissue healing but there are numerous doubts among clinical orthopedists about effectiveness of this method. Materials and methods: The studies were carried out in 12 rabbits of white termond breed. In operating room we operationally generated cylindrical, unicortical defects of the diameter of 4 mm in the middle of the shafts of both femurs. The defects in the left bones were left without filling and served as controls, and 0.7 ml of the ready-to-use PRP was administered to the defects in the right bones (experimental group). We evaluated the usefulness of the diagnostic methods applied: biomechanical tests, micro-CT tests, densitometry, typical radiology, macroscopic measurements, histopathological examinations. Results: The macroscopic measurements showed a statistically significant increase in the dimension in the area of the right defect filled with PRP in relation to the control group. In experimented group, the assessment of the X-ray images showed the formation of a callus cuff around the defects. Densitometric examinations showed no statistically significant differences between defects in the experimental and control group. The analysis of the micro-CT examina- tions showed an increase in the total volume of the tissue examined (Vb) and the low density tissue fraction (Vb2) in the experimental group. The biomechanical examinations revealed signi- ficant decrease in the maximum breaking force (F max) necessary to break the bone in the experi- mental group in relation to the control group. Conclusions: Platelet-rich plasma (PRP) stimulates bone formation in the area of bone defects and may accelerate bone regeneration. L1 - http://www.czasopisma.pan.pl/Content/110877/PDF/15.pdf L2 - http://www.czasopisma.pan.pl/Content/110877 PY - 2019 IS - No 1 EP - 115 DO - 10.24425/pjvs.2019.127077 KW - platelet-rich plasma KW - bone regeneration KW - bone defects KW - rabbit model A1 - Skwarcz, S. A1 - Bryzek, I. A1 - Gregosiewicz, A. A1 - Warda, E. A1 - Gawęda, K. A1 - Tarczyńska, M. A1 - Węgłowski, R. A1 - Skwarcz, J. A1 - Nadulski, R. A1 - Starek, A. A1 - Sanford, J. PB - Polish Academy of Sciences Committee of Veterinary Sciences PB - University of Warmia and Mazury in Olsztyn VL - vol.22 DA - 2019.04.04 T1 - Autologous activated platelet-rich plasma (PRP) in bone tissue healing – does it work? Assessment of PRP effect on bone defect healing in animal models SP - 109 UR - http://www.czasopisma.pan.pl/dlibra/publication/edition/110877 T2 - Polish Journal of Veterinary Sciences ER -