TY - JOUR N2 - Pigmented villonodular synovitis (PVNS) is a benign disease that rarely undergoes malignant transformation. Th ere are two types of disease: localized (nodular tenosynovitis) and diff used (pigmented villonodular synovitis/tenosynovitis) with intra- or extra-articular locations. Th e second one is limited to synovium of the burse (PVNB) or tendon sheath (PVNTS). Th e intraarticular lesions are usually located in the knee, hip, ankle and elbow joints. Histologically, PVNS is a tenosynovial giant cell tumor, characterized by proliferation of two types of mononuclear cells — predominantly small, histiocyte-like cells and larger cells with dense cytoplasm, reniform or lobulated nucleus, with accompanying multinucleated giant cells and macrophages overloaded with hemosiderin that give typical image on MRI — currently selected as a gold standard for its diagnosis. Th e classic X-ray and CT are non-specifi c but similar to ultrasound should be used to evaluate disease progression and treatment response if radiotherapeutic and pharmacological methods were selected for treatment. An open arthroscopic surgery could also be applied in selected cases. L1 - http://www.czasopisma.pan.pl/Content/109691/PDF/FMC%204-18%209-Falek.pdf L2 - http://www.czasopisma.pan.pl/Content/109691 PY - 2018 IS - No 4 EP - 104 DO - 10.24425/fmc.2018.125707 KW - pigmented villonodular synovitis KW - PVNS KW - tenosynovial giant cell tumor KW - epidemiology KW - diagnosis A1 - Fałek, Artur A1 - Niemunis-Sawicka, Joanna A1 - Wrona, Katarzyna A1 - Szczypiór, Grzegorz A1 - Rzepecka-Wejs, Ludomira A1 - Cięszczyk, Katarzyna A1 - Burdan, Maciej A1 - Puderecki, Michał A1 - Burzec, Paulina A1 - Marzec-Kotarska, Barbara A1 - Szumiło, Justyna A1 - Burdan, Franciszek PB - Oddział PAN w Krakowie; Uniwersytet Jagielloński – Collegium Medicum VL - vol. 58 DA - 2018.12.15 T1 - Pigmented villonodular synovitis SP - 93 UR - http://www.czasopisma.pan.pl/dlibra/publication/edition/109691 T2 - Folia Medica Cracoviensia ER -