TY - JOUR N2 - Canine distemper virus (CDV) infects wild and domestic Canidae worldwide. The hemag- glutinin (H) gene has the highest genetic variation in the genome of this virus. Thus, the H gene is commonly used for lineage identification and genetic analyses. In order to study the genetic characteristics and pathogenicity of CDV strains prevalent in China, 132 samples were collected from domestic dogs with suspected CDV infection, 58 samples were confirmed to be positive, and the H gene was successfully amplified from 15 samples. The epidemic strain was identified as type Asia-1 and the novel mutations, A51T, V58I, R179K and D262N, were detected in this strain. Isolated strains, BJ16B53, BJ16B14, and BJ17B8, were used for an animal infection experiment in raccoon dogs. BJ16B53 and BJ16B14 were found to cause clinical symptoms, death, and exten- sive lesions in various organs. These results are expected to facilitate the development of effective strategies to monitor and control CDV infection in China. L1 - http://www.czasopisma.pan.pl/Content/108455/PDF/26.pdf L2 - http://www.czasopisma.pan.pl/Content/108455 PY - 2018 IS - No 3 EP - 623–629 DO - 10.24425/124301 KW - canine distemper virus KW - hemagglutinin KW - phylogenetic analysis KW - animal infection A1 - Chen, M. A1 - Xin, T. A1 - Hou, S. A1 - Lin, W. A1 - Song, W. A1 - Zhu, H. A1 - Huang, K. A1 - Jia, H. PB - Polish Academy of Sciences Committee of Veterinary Sciences PB - University of Warmia and Mazury in Olsztyn VL - vol. 21 DA - 2018.11.20 T1 - Genotyping and pathogenic characterization of canine distemper virus based on mutations in the hemagglutinin gene in Chinese domestic dogs SP - 623–629 UR - http://www.czasopisma.pan.pl/dlibra/publication/edition/108455 T2 - Polish Journal of Veterinary Sciences ER -